Safety Recommendations for Administering Intravenous Prostacyclins in the Hospital
Learning ObjectivesAt the completion of this program, you will be able to:
- Distinguish between adverse effects of prostacyclins and symptoms of pulmonary artery hypertension
- Summarize 4 approaches to prevent errors associated with high-risk medications
- Describe 3 safety recommendations that reduce error during prostacyclin administration
Continuing Education Information
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Prostacyclins are a high-risk category of continuous intravenous infusions increasingly used in hospitals to
treat advanced pulmonary arterial hypertension, a rare condition characterized by vasoconstriction and vascular proliferation of the pulmonary arteries. Prostacyclins are given in doses of nanograms per kilogram per minute and have a narrow therapeutic dosing range for each patient. Sudden increases or decreases in dose can be life threatening. Previous studies revealed errors in the administration of these high-risk infusions, which in some instances led to serious adverse events, including death. We reviewed the literature for safety measures in administration of high-risk intravenous medications and obtained input from leading experts in pulmonary arterial hypertension to create
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