Norepinephrine Dosing in Obese and Nonobese Patients With Septic Shock

Author(s): John J. Radosevich, PharmD, Asad E. Patanwala, PharmD, and Brian L. Erstad, PharmD

Contact Hours 1.00

CERP A 1.00

Pharmacology Hours 1.00

Expires Jan 01, 2019

Topics: Pharmacology, Sepsis

Population: Adult

Role: Staff, APRN

Member: Free
NonMember: $10.00

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Activity Summary

Whether or not norepinephrine infusions for support of hemodynamic status in patients with septic shock should be weight based is unknown. This situation is particularly pertinent in patients who are extremely overweight or obese.


  • Identify logistical issues and challenges with using weight-based dosing of norepinephrine in the obese.
  • Determine if non-weight based dosing and titration of norepinephrine is appropriate in obese patients.
  • Explain the relationship between drug concentrations of norepinephrine and effect on mean arterial pressure.

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