Meta-Analysis of ICU Delirium Biomarkers and Their Alignment with the NIA-AA Research Framework

Author(s): Carol K. Chan, MBBCh, MSc, Yiqing Song, MD, ScD, Ryan Greene, PsyD, Heidi Lindroth, PhD, RN, Sikandar Khan, DO, MS, Gabriel Rios, MLIS, Babar Khan, MD, MS, and Sophia Wang, M

Contact Hours 1.00

CERP A 1.00

Expires Jun 28, 2024

Topics: Delirium

Member: Free
NonMember: $10.00

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Activity Summary

Required reading for all learners: Implicit Bias impacts patient outcomes

30-80% of survivors of critical illness experience cognitive impairment, but the underlying mechanisms remain unknown.  We conducted a systematic review and meta-analysis on whether ICU delirium biomarkers aligned with the National Institute on Aging-Alzheimer’s Association (NIA-AA) research framework for diagnostic biomarkers for Alzheimer’s disease and other related dementias (ADRD). In pooled analysis, there was a significant association between ICU delirium and Aβ1-40  , IL-RA and IL-6.  These findings point to potential overlapping mechanisms between delirium and ADRD.


  • Describe the rationale for examining the overlap in biomarker profile of intensive care unit (ICU) delirium and dementia
  • Identify fluid biomarkers associated with ICU delirium and dementia
  • Identify areas for future biomarker research in the field of ICU delirium and post-ICU cognitive impairment

Continuing Education Disclosure Statement

Successful Completion

Learners must attend/view/read the entire activity, read Implicit Bias impacts patient outcomes, and complete the associated evaluation to be awarded the contact hours or CERP. No partial credit will be awarded.


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Provider approved by the California Board of Registered Nursing, Provider number CEP 1036, for 1.00 contact hours.

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