Meta-Analysis of ICU Delirium Biomarkers and Their Alignment with the NIA-AA Research Framework

Author(s): Carol K. Chan, MBBCh, MSc, Yiqing Song, MD, ScD, Ryan Greene, PsyD, Heidi Lindroth, PhD, RN, Sikandar Khan, DO, MS, Gabriel Rios, MLIS, Babar Khan, MD, MS, and Sophia Wang, M

Contact Hours 1.00

CERP A 1.00

Expires Jun 28, 2023

Topics: Delirium

Member: Free
NonMember: $10.00

Added to Collection

Activity Summary

Required reading for all learners: Implicit Bias impacts patient outcomes

30-80% of survivors of critical illness experience cognitive impairment, but the underlying mechanisms remain unknown.  We conducted a systematic review and meta-analysis on whether ICU delirium biomarkers aligned with the National Institute on Aging-Alzheimer’s Association (NIA-AA) research framework for diagnostic biomarkers for Alzheimer’s disease and other related dementias (ADRD). In pooled analysis, there was a significant association between ICU delirium and Aβ1-40  , IL-RA and IL-6.  These findings point to potential overlapping mechanisms between delirium and ADRD.


  • Describe the rationale for examining the overlap in biomarker profile of intensive care unit (ICU) delirium and dementia
  • Identify fluid biomarkers associated with ICU delirium and dementia
  • Identify areas for future biomarker research in the field of ICU delirium and post-ICU cognitive impairment

Continuing Education Disclosure Statement

Successful Completion

Learners must attend/view/read the entire activity and complete the associated evaluation to be awarded the contact hours or CERP. No partial credit will be awarded.


This activity has been reviewed by the Nurse Planner. It has been determined that the material presented here shows no bias. No conflicts of interest have been identified for any individual with the ability to influence the content of this activity. Accreditation refers to recognition of continuing education only and does not imply AACN or ANCC approval or endorsement of any commercial products discussed or displayed in conjunction with this educational activity.


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