Meta-Analysis of ICU Delirium Biomarkers and Their Alignment with the NIA-AA Research Framework

Activity Summary

Required reading for all learners: Implicit Bias impacts patient outcomes

30-80% of survivors of critical illness experience cognitive impairment, but the underlying mechanisms remain unknown. We conducted a systematic review and meta-analysis on whether ICU delirium biomarkers aligned with the National Institute on Aging-Alzheimer’s Association (NIA-AA) research framework for diagnostic biomarkers for Alzheimer’s disease and other related dementias (ADRD). In pooled analysis, there was a significant association between ICU delirium and Aβ1-40 , IL-RA and IL-6. These findings point to potential overlapping mechanisms between delirium and ADRD.

Objectives

Describe the rationale for examining the overlap in biomarker profile of intensive care unit (ICU) delirium and dementia
Identify fluid biomarkers associated with ICU delirium and dementia
Identify areas for future biomarker research in the field of ICU delirium and post-ICU cognitive impairment

Continuing Education Disclosure Statement

Successful Completion

Learners must attend/view/read the entire activity and complete the associated evaluation to be awarded the contact hours or CERP. No partial credit will be awarded.

Disclosure

This activity has been reviewed by the Nurse Planner. It has been determined that the material presented here shows no bias. No conflicts of interest have been identified for any individual with the ability to influence the content of this activity. Accreditation refers to recognition of continuing education only and does not imply AACN or ANCC approval or endorsement of any commercial products discussed or displayed in conjunction with this educational activity.

Accreditation

The American Association of Critical-Care Nurses (AACN) is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's (ANCC's) Commission on Accreditation, ANCC Provider Number 0012. AACN has been approved as a provider of continuing education in nursing by the California State Board of Nursing (CBRN), California Provider number CEP 1036. This activity is approved for 1.00 contact hours.

AACN programming meets the standards for most states that require mandatory continuing education contact hours for license and/or certification renewal. AACN recommends consulting with your state board of nursing or credentialing organization before submitting CE to fulfill continuing education requirements.

Refund Policy

Continuing Education Activities are nonrefundable.