Newer Intravenous Antibiotics in the Intensive Care Unit: Ceftaroline, Ceftolozane-Tazobactam, and Ceftazidime-Avibactam

Author(s): Kathryn A. Connor, PharmD

Contact Hours 1.00

CERP A 1.00

Pharmacology Hours 1.00

Expires Oct 01, 2019

Topics: Infectious Disease, Pharmacology

Population: Adult

Role: APRN

Member: Free
NonMember: $10.00

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Activity Summary

A global crisis of antibiotic resistance is ongoing, especially with resistant gram-negative pathogens including Pseudomonas spp, carbapenemase producing Enterobacteriaceae, and extended-spectrum β-lactamase (ESBL)-producing organisms. The increasing rate of methicillin-resistant Staphylococcus aureus (MRSA) infections is also a concern.1 One newer intravenous cephalosporin (ceftaroline) was approved in 2010, and 2 new intravenous cephalosporin–β-lactamase inhibitor combinations (ceftolazone-tazobactam and ceftazidime-avibactam) have recently been approved to try to combat these resistant organisms in adult patients.


  • Compare and contrast the spectrum of activity of newer IV antibiotics in the ICU.
  • Discuss the role, including indications and place in therapy, of newer IV antibiotics in the ICU.
  • Summarize the safety implications associated with newer IV antibiotics in the ICU.

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