Clostridium Difficile Infection: Clinical Challenges and Management Strategies

Author(s): Pamela R. Walters, RN, BSN, CCRN, Brian S. Zuckerbraun, MD

Contact Hours 1.00

CERP A 1.00

Expires Aug 01, 2018

Topics: Gastrointestinal, Infectious Disease

Population: Adult

Role: Staff

Member: Free
NonMember: $10.00

Added to Collection

Activity Summary

Clostridium difficile has become the leading cause of nosocomial diarrhea in adults. A substantial increase has occurred in morbidity and mortality associated with disease caused by C difficile and in the identification of new hypervirulent strains, warranting a high clinical index of suspicion for infections due to this organism. Prevention of infection requires a multidisciplinary approach, including early recognition of disease, effective contact isolation precautions, adherence to disinfectant policies, and judicious use of antibiotics. Current treatment approaches are based on the severity of illness. As hypervirulent strains evolve, unsuccessful treatments are more common. Complicated colitis caused by C difficile may benefit from surgical intervention. Subtotal colectomy and end ileostomy have been the procedures of choice, but are associated with a high mortality rate because of late surgical consultation and use of surgery as a salvage therapy. A promising surgical alternative is creation of a diverting loop ileostomy with colonic lavage.


  • Identify symptoms of Clostridium difficile infection (CDI)
  • Describe strategies to prevent transmission of CDI
  • Identify treatment options for CDI

Continuing Education Disclosure Statement

Successful Completion

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