Extracorporeal life support (ECLS) is increasingly being used for refractory cardiopulmonary failure and its use in the adult population is gaining attention in clinical practice. The paucity of randomized clinical trials and guidelines has led to significant practice variation when trying to address the challenge of minimizing risk and maximizing benefit. This course provides the necessary framework for management of a patient requiring ECLS through the use of practical case-based scenarios, high-fidelity hands-on simulations, and discussion of current hot topics.