Update of Antiepileptic Drug Dosing and Administration

Author(s): Gabriela Saavedra, PharmD, Robert M. Woods, PharmD, BCPS, Kyle A. Hultz, PharmD

Contact Hours 1.00

CERP A 1.00

Pharmacology Hours 1.00

Expires Mar 01, 2026

Topics: Neurology

Role: Staff, APRN

Member: Free
NonMember: $10.00

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Activity Summary

Required reading for all learners: Implicit Bias impacts patient outcomes

Since the American Epilepsy Society guidelines were published in 2016, new studies of dosing and administration of antiepileptic drugs for managing status epilepticus (SE) have been published. To prevent poor neurological 0utcomes, healthcare providers must recognize, treat, and attempt to terminate seizures when they occur. It is vital to choose an optimal agent and administer the agent as safely and quickly as possible. Common antiepileptics used in SE can be safely administered via intravenous push (IVP). Other agents, such as fosphenytoin and valproic acid, can be safely administered faster than the package insert recommendations but may require multiple doses to be prepared at the bedside or 1 dose to be sent from the pharmacy. In this article we propose an algorithm for administration of recommended antiepileptic drugs with dosing, special storage requirements, and other considerations for the treatment of SE in inpatient adults.


  • Summarize the first-line treatment recommendations for the management of status epilepticus.
  • Identify the anti-epileptic medications used as second-line treatment options in managing status epilepticus.
  • Describe alternative dosing and administration techniques of second-line anti-epileptics based on recently published literature.

Continuing Education Disclosure Statement

Successful Completion

Learners must attend/view/read the entire activity, read Implicit Bias impacts patient outcomes, and complete the associated evaluation to be awarded the contact hours or CERP. No partial credit will be awarded.


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Provider approved by the California Board of Registered Nursing, Provider number CEP 1036, for 1.00 contact hours.

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