New and Off-Label Uses of Tranexamic Acid

Author(s): Stephanie M. Johnson, PharmD, Dawn Tsang, PharmD, BCPS, Mary Dansby, PharmD, BCPS, Christopher Allen, PharmD, BCPS, BCNSP

Contact Hours 1.00

CERP A 1.00

Pharmacology Hours 1.00

Expires Sep 01, 2024

Topics: Hemodynamics, Pharmacology, Trauma

Member: Free
NonMember: $10.00

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Activity Summary

Required reading for all learners: Implicit Bias impacts patient outcomes

While the FDA approved uses of tranexamic acid are limited, off label use has applications to patients in critical care, particularly trauma and surgical patients. This article describes the mechanism of action of TXA and summarizes the research on off-label use. Considerations such as adverse events, the timing of administration and contraindications are also discussed.


  • Describe the pharmacokinetics, safety, and approved indications for tranexamic acid
  • Evaluate the current evidence related to the off-label use of tranexamic acid in trauma-related bleeding, surgery, and postpartum hemorrhage
  • Identify the role of tranexamic acid in new off-label uses including hemoptysis and epistaxis

Continuing Education Disclosure Statement

Successful Completion

Learners must attend/view/read the entire activity, read Implicit Bias impacts patient outcomes, and complete the associated evaluation to be awarded the contact hours or CERP. No partial credit will be awarded.


The American Association of Critical-Care Nurses is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.

Provider approved by the California Board of Registered Nursing, Provider number CEP 1036, for 1.00 contact hours.

Accreditation refers to recognition of continuing education only and does not imply AACN, ANCC, or CBRN approval or endorsement of any commercial products discussed or displayed in conjunction with this educational activity.


Any relevant relationship between an ineligible company and an individual with the ability to influence clinical content will be identified by the Nurse Planner within the activity. Any relevant relationship between an ineligible company and an individual with the ability to influence clinical content has been mitigated.

AACN programming meets the standards for most states that require mandatory continuing education contact hours for license and/or certification renewal. AACN recommends consulting with your state board of nursing or credentialing organization before submitting CE to fulfill continuing education requirements.

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Continuing Education Activities are nonrefundable.